HENDERSON, Nev, Nov. 17, 2023 /PRNewswire/ — VolitionRx Limited (NYSE AMERICAN: VNRX) (“Volition”), a multi-national epigenetics company, is presenting at the 5th Annual Congress of Liquid Biopsy being held in Madrid, Spain.
Lea Payen-Gay, Professor in Toxicology and Biochemistry, University of Lyon I Hospices Civils de Lyon, France and Dr. Jake Micallef, Chief Scientific Officer, Volition will present a one-hour session entitled “An Introduction to circulating nucleoproteins” on Monday November 20, 2023.
Dr. Jake Micallef, Chief Scientific Officer at Volition, said: “We recently unveiled what we believe to be an entirely new cancer detection method1. This data has generated significant interest from large diagnostic and liquid biopsy companies alike. We are delighted to be presenting at the International Liquid Biopsy Society’s Congress and furthering these discussions.”
In early-stage cancer, it is difficult to detect cancer-derived circulating tumor DNA (ctDNA) in the blood because it may comprise as little as 0.01% of the DNA present among a background of 99.99% normal DNA. Moreover, most of the cancer DNA has exactly the same sequence as normal DNA.
As physical separation of tumor-derived and healthy circulating DNA has never before been achieved, current ctDNA detection methods involve DNA extraction, sequencing of all (cancer and normal) circulating DNA then analysis of the sequencing data using sophisticated computer bioinformatics, to tell them apart.
Volition has developed a novel method for liquid biopsy involving the first reported physical isolation of a class of tumor-derived ctDNA fragments from blood. Cancer-derived ctDNA fragments are then extracted after removal of all normal background DNA of the same sequence for detection with a simple, low cost PCR test.
Volition’s proof of concept data1, demonstrates the isolation of tumor-derived ctDNA fragments from plasma. Volition tested the new method in a first small clinical experiment and detected a range of liquid and other cancers, including at early stage I disease. For example, 74% of leukemias were detected at 96% specificity and 77% of colorectal cancers were detected at 92% specificity with 2-qPCR assays.
Notes:
1. ‘A novel immunoprecipitation/PCR method for detection of plasma cfDNA fragments selectively occupied by CTCF in cancer.’ D Pamart et al. ESMO 2023
About Volition
Volition is a multi-national epigenetics company focused on advancing the science of epigenetics. Volition is dedicated to saving lives and improving outcomes for people and animals with life-altering diseases through earlier detection, as well as disease and treatment monitoring.
Through its subsidiaries, Volition is developing and commercializing simple, easy to use, cost-effective blood tests to help diagnose and monitor a range of diseases, including some cancers and diseases associated with NETosis, such as sepsis. Early diagnosis and monitoring have the potential to not only prolong the life of patients, but also improve their quality of life.
Volition’s research and development activities are centered in Belgium, with an innovation laboratory and office in the U.S. and additional offices in London and Singapore.
The contents found at Volition’s website address are not incorporated by reference into this document and should not be considered part of this document. Such website address is included in this document as an inactive textual reference only.
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